ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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G-protein coupled receptor homolog US28

Intermolecular
Cysteine 351 of Guanine nucleotide-binding protein G(i) subunit alpha-1 and cysteine 66
Cysteine 36 of Fractalkine and cysteine 263
Cysteine 74 of Fractalkine and cysteine 263
A redox-regulated disulphide may form between cysteine 351 of Guanine nucleotide-binding protein G(i) subunit alpha-1 and cysteine 66 of G-protein coupled receptor homolog US28. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7rkm
Structure name
structure of cx3cl1-us28-gi-scfv16 in c-state
Structure deposition date
2021-07-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
100
Peptide A name
Guanine nucleotide-binding protein G(i) subunit alpha-1
Peptide B name
G-protein coupled receptor homolog US28
Peptide A accession
P63096
Peptide B accession
P69332
Peptide A residue number
351
Peptide B residue number
66

Ligandability

Cysteine 351 of Guanine nucleotide-binding protein G(i) subunit alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of G-protein coupled receptor homolog US28

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 36 of Fractalkine and cysteine 263 of G-protein coupled receptor homolog US28 (12 and 263 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7rkf
Structure name
structure of cx3cl1-us28-g11in18-scfv16 in tl-state
Structure deposition date
2021-07-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide A name
Fractalkine
Peptide B name
G-protein coupled receptor homolog US28
Peptide A accession
P78423
Peptide B accession
P69332
Peptide A residue number
36
Peptide B residue number
263

Ligandability

Cysteine 36 of Fractalkine

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 263 of G-protein coupled receptor homolog US28

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 74 of Fractalkine and cysteine 263 of G-protein coupled receptor homolog US28 (50 and 263 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7rkm
Structure name
structure of cx3cl1-us28-gi-scfv16 in c-state
Structure deposition date
2021-07-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide A name
Fractalkine
Peptide B name
G-protein coupled receptor homolog US28
Peptide A accession
P78423
Peptide B accession
P69332
Peptide A residue number
74
Peptide B residue number
263

Ligandability

Cysteine 74 of Fractalkine

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 263 of G-protein coupled receptor homolog US28

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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